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Avidin Fusion Protein-Expressing Lentiviral Vector for Targeted Drug Delivery

✍ Scribed by Lesch, Hanna P.; Pikkarainen, Jere T.; Kaikkonen, Minna U.; Taavitsainen, Miia; Samaranayake, Haritha; Lehtolainen-Dalkilic, Pauliina; Vuorio, Taina; Määttä, Ann-Marie; Wirth, Thomas; Airenne, Kari J.; Ylä-Herttuala, Seppo

Book ID
120396054
Publisher
Mary Ann Liebert
Year
2009
Tongue
English
Weight
636 KB
Volume
20
Category
Article
ISSN
1043-0342

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## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote