## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote
IgG-Paraoxonase-1 Fusion Protein for Targeted Drug Delivery across the Human Blood−Brain Barrier
✍ Scribed by Boado, Ruben J.; Zhang, Yun; Zhang, Yufeng; Wang, Yuntao; Pardridge, William M.
- Book ID
- 127001821
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 256 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1543-8384
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mucopolysaccharidosis Type I, Hurler's Syndrome, is a lysosomal storage disorder that affects the brain. The missing enzyme, α‐L‐iduronidase (IDUA), does not cross the blood‐brain barrier (BBB). To enable BBB transport of the enzyme, human IDUA was fused to the carboxyl terminus of the
## Abstract A murine monoclonal antibody (MAb) to the human insulin receptor (HIR) has been engineered for use as a brain drug delivery system for transport across the human blood–brain barrier (BBB). The HIRMAb was humanized by complementarity determining region (CDR) grafting on the framework reg