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Genetic Engineering, Expression, and Activity of a Chimeric Monoclonal Antibody−Avidin Fusion Protein for Receptor-Mediated Delivery of Biotinylated Drugs in Humans

✍ Scribed by Boado, Ruben J.; Zhang, Yufeng; Zhang, Yun; Xia, Chun-fang; Wang, Yuntao; Pardridge, William M.


Book ID
126962257
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
687 KB
Volume
19
Category
Article
ISSN
1043-1802

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## Abstract Protein therapeutics may be delivered across the blood–brain barrier (BBB) by genetic fusion to a BBB molecular Trojan horse. The latter is an endogenous peptide or a peptidomimetic monoclonal antibody (MAb) against a BBB receptor, such as the insulin receptor or the transferrin recepto

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## Abstract Neurotrophins, such as brain derived neurotrophic factor (BDNF), do not cross the blood–brain barrier (BBB). Certain monoclonal antibodies (MAb) to the human insulin receptor (HIR) do cross the BBB via receptor‐mediated transport, and can act as a molecular Trojan horse to ferry across