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Autoradiographic localization of apamin-sensitive Ca2+-dependent K+ channels in rat brain

✍ Scribed by Christiane Mourre; Heidy Schmid-Antomarchi; Michel Hugues; Michel Lazdunski

Book ID
115878536
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
157 KB
Volume
100
Category
Article
ISSN
0014-2999

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In rat pituitary gonadotropes, gonadotropin-releasing hormone (GnRH) stimulates rhythmic release of Ca2+ from stores sensitive to inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], which in turn induces an oscillatory activation of apamin-sensitive Ca2+-activated K+ current, IK(Ca). Since GnRH also activa