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Apamin-Sensitive Ca2+-Dependent K+Current and Hyperpolarization in Human Endothelial Cells

✍ Scribed by K. Muraki; Y. Imaizumi; S. Ohya; K. Sato; T. Takii; K. Onozaki; M. Watanabe

Book ID
115580539
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
97 KB
Volume
236
Category
Article
ISSN
0006-291X

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In rat pituitary gonadotropes, gonadotropin-releasing hormone (GnRH) stimulates rhythmic release of Ca2+ from stores sensitive to inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], which in turn induces an oscillatory activation of apamin-sensitive Ca2+-activated K+ current, IK(Ca). Since GnRH also activa