Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy
β Scribed by Messina, C; Cesaro, S; Rondelli, R; Rossetti, F; Locatelli, F; Pession, A; Miniero, R; Dini, G; Uderzo, C; Dallorso, S
- Book ID
- 110010522
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 62 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0007-1188
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Ten patients age 13-52 years with acute lymphoblastic leukemia (ALL) in first complete remission (CR) (1), second CR (6), or relapse (3) were treated with cyclophosphamide 50 mg/kg daily x 4 and total body irradiation 3 Gy daily x 4 followed by infusion of autologous marrow purged with 4-hydroperoxy
Seven patients with relapsed acute leukaemia were treated with high-dose melphalan (HDM) followed by the infusion of autologous cryopreserved remission marrow. Toxicy was minimal and all seven patients had a complete response. Four patients are still in unmaintained remission at 14, 13, 10, and 3 mo