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High-dose melphalan and autologous bone marrow transplant for relapsed acute leukaemia

✍ Scribed by Dominique Maraninchi; Manuel Abecasis; Jean-Albert Gastaut; Gérard Sebahoun; Jean-Yves Cahn; Patrick Hervé; Gisèle Novakovitch; Yves Carcassonne

Publisher
Springer
Year
1983
Tongue
English
Weight
246 KB
Volume
10
Category
Article
ISSN
0344-5704

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✦ Synopsis

Seven patients with relapsed acute leukaemia were treated with high-dose melphalan (HDM) followed by the infusion of autologous cryopreserved remission marrow. Toxicy was minimal and all seven patients had a complete response. Four patients are still in unmaintained remission at 14, 13, 10, and 3 months, the first two having received a second course of HDM to consolidate the result. The role of HDM as a form of intensification therapy for patients with acute myeloid leukaemia in first remission should be investigated.

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High-dose melphalan, vincristine, and total-body irradiation with autologous bone marrow transplantation in children with relapsed neuroblastoma: A phase II study
✍ Pinkerton, C. R. ;Philip, T. ;Biron, P. ;Frapazz, D. ;Phillipe, N. ;Zucker, J. M 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

Seven children with neuroblastoma who had relapsed on or after conventional therapy (3 originally stage IV, 3 stage III, 1 stage II) were entered on a study of "massive therapy" with purged autologous bone marrow rescue. In 5 patients attempts were made to reinduce remission with alternative chemoth