Thirty-four children with acute lymphoblastic leukaemia (ALL) in relapse or resistant to initial induction received combination chemotherapy with prednisolone, vincristine, l-asparaginase, and daunorubicin. L-asparaginase was given subcutaneously on alternate days for four weeks and was well tolerat
Chemotherapy versus bone marrow transplantation in childhood acute lymphoblastic leukaemia
β Scribed by W. Ebell; A. Reiter; H. Riehm;
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 578 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0340-6997
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Early reports would suggest that closely matched UD BMT is an adequate substitute for MSD BMT in children with relapsed ALL. Protagonists of BMT might suggest that UD BMT be used in the absence of a MSD in all cases of BM relapse of ALL. However, recent improvements in chemoradiotherapy schedules ha
The bone marrow chromosomes of 25 children with acute lymphoblastic leukaemia (ALL) were examined at diagnosis before treatment, during remission, and in 12 cases, also during relapse. Follow-up was for at least six years. At diagnosis, 17 patients had a major population of chromosomally abnormal ce