Autoimmunity and familial risk of type 1 diabetes
✍ Scribed by Anu-Maaria Hämäläinen; Mikael Knip
- Book ID
- 107535882
- Publisher
- Current Science Inc.
- Year
- 2002
- Tongue
- English
- Weight
- 427 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1534-4827
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The prevalence rate for autoimmune thyroid disease (ATD) is about 30 times higher in the type I diabetic (IDDM) families that were ascertained for Genetic Analysis Workshop 5 (GAW5) than in the general population. Two approaches were used to study the clustering of ATD and IDDM in these families: 1)
Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several &cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of