✦ LIBER ✦

T-cell autoimmunity in type 1 diabetes mellitus

✍ Scribed by Ohad S. Birk; Irun R. Cohen

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 890 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90104-z

No coin nor oath required. For personal study only.

✦ Synopsis

Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several &cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of diabetes. The question, then, is why and how exposure to undefined environmental agents activates an existing autoimmune potential and directs it to damage the b cells. Current Opinion in Immunology 1993, 5:903-909 Abbreviations BB-bio-breeding; EAEL-experimental allergic encephalomyelitis; GAD-glutamic acid decarboxylase; hspheat-shock protein; IDDM-insulin dependent diabetes mellitus; MBP-myelin basic protein; NOD-non-obese diabetic.

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