Autoantibodies in primary biliary cirrhosis
β Scribed by Berg, PeterA. ;Klein, Reinhild
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 923 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0344-4325
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A major enigma of primary biliary cirrhosis (PBC) is the selective targeting of biliary cells. Our laboratory has reported that after apoptosis, human intrahepatic biliary epithelial cells (HiBECs) translocate the E2 subunit of the pyruvate dehydrogenase complex immunologically intact into apoptotic
Autoantibodies against nuclear pore membrane glycoprotein gp210 have been identified in between 10% and 25% of patients with primary biliary cirrhosis (PBC). These antibodies may be useful in diagnosing PBC and in identifying subgroups of patients. Because previous detection procedures relied on the
S i x components of the mammalian 2-0x0 acid dehydrogenase complexes have previously been identified as M2 autoantigens in primary biliary cirrhosis. In this report, we present data showing that both polypeptidespecific and cross-reacting antibodies are present in patients' sera. Antibodies reacting
An antinuclear immunofluorescence pattern displaying a thin ring confined to the nuclear envelope was assessed in sera from 38 patients with primary biliary cirrhosis and in sera from a control group of 277 patients with other antinuclear antibody-positive diseases. This rim-like antinuclear reactiv