Anti-pyruvate dehydrogenase autoantibodies in primary biliary cirrhosis
โ Scribed by N. Zurgil; R. Bakimer; M. Kaplan; P. Youinou; Y. Shoenfeld
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 778 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0271-9142
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๐ SIMILAR VOLUMES
Sera from patients with primary biliary cirrhosis inhibit the activity of the mitochondrial pyruvate dehydrogenase complex. We utilized this effect to develop a simple, miniaturized, semiautomated spectrophotometric assay as a diagnostic aid. The sera studied were from 71 patients with primary bilia
Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associat
Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c
Primary biliary cirrhosis is a chronic autoimmune disease in which serum autoantibodies against the mitochondrial2-0x0 acid dehydrogenase enzyme complexes (M2 antibodies) are regularly present. Molecular mimicry of host proteins by bacterial counterparts is a suggested explanation for the origin of