Biosynthetic studies on mithramycin (1, aureolic acid) using to a great extent modern genetic methods revealed several novel aspects of the biosynthesis of this class of antitumor agent. It could be proven that the aglycon moiety of the aureolic acids is constructed by a type II polyketide synthase
β¦ LIBER β¦
Aureolic Acid Group of Anti-tumour Antibiotics
β Scribed by BERLIN, Yu. A.; KISELEVA, O. A.; KOLOSOV, M. N.; SHEMYAKIN, M. M.; SOIFER, V. S.; VASINA, I. V.; YARTSEVA, I. V.; KUZNETSOV, V. D.
- Book ID
- 109662473
- Publisher
- Nature Publishing Group
- Year
- 1968
- Tongue
- English
- Weight
- 233 KB
- Volume
- 218
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/218193a0
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