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Aureolic acid antibiotics: synthesis of naphthocyclobutene precursors

✍ Scribed by Datta, Subhash C.; Franck, Richard W.; Noire, Paul D.


Book ID
126305183
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
980 KB
Volume
49
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


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Biosynthetic studies on mithramycin (1, aureolic acid) using to a great extent modern genetic methods revealed several novel aspects of the biosynthesis of this class of antitumor agent. It could be proven that the aglycon moiety of the aureolic acids is constructed by a type II polyketide synthase

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AURROLIC acid (mithramycin, LA-7M7), chromomycins (aburamycins) end olivolqycins (NSC A-649) comprise a single group of anti-tuawur antibiotics of