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Attenuated expression of the serum responsive T1 gene in ras transformed fibroblasts due to the inhibition of c-fos gene activity

✍ Scribed by Kessler, Reto; Zacharova-Albinger, Andrea; Laursen, Niels B; Kalousek, Markus; Klemenz, Roman


Book ID
110061932
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
391 KB
Volume
18
Category
Article
ISSN
0950-9232

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Alterations in the molecular response to
✍ Augustine M. K. Choi; Robert J. Pignolo; Colette M. J. Ap Rhys; Vincent J. Crist πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 993 KB

Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1