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Attempted De Novo design, synthesis, and evaluation of a ligand for the allosteric site of phosphofructokinase

✍ Scribed by Sampson, Nicole S.; Bartlett, Paul A.


Book ID
127176611
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
774 KB
Volume
56
Category
Article
ISSN
0022-3263

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In this report refinements to the S4 ligand group leads to compound 19, an inhibitor of fXa with good potency in vitro and an improved pharmacokinetic profile in rabbit. The X-ray crystallographic study of a representative analogue confirms our binding model for this series.