Homology Modeling of Falcipain-2: Validation, De Novo Ligand Design and Synthesis of Novel Inhibitors
β Scribed by Sabnis, Yogesh; Rosenthal, Philip J.; Desai, Prashant; Avery, Mitchell A.
- Book ID
- 120346549
- Publisher
- Adenine Press
- Year
- 2002
- Tongue
- English
- Weight
- 729 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0739-1102
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π SIMILAR VOLUMES
In this report refinements to the S4 ligand group leads to compound 19, an inhibitor of fXa with good potency in vitro and an improved pharmacokinetic profile in rabbit. The X-ray crystallographic study of a representative analogue confirms our binding model for this series.
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