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Homology Modeling of Falcipain-2: Validation, De Novo Ligand Design and Synthesis of Novel Inhibitors

✍ Scribed by Sabnis, Yogesh; Rosenthal, Philip J.; Desai, Prashant; Avery, Mitchell A.


Book ID
120346549
Publisher
Adenine Press
Year
2002
Tongue
English
Weight
729 KB
Volume
19
Category
Article
ISSN
0739-1102

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The de novo design and synthesis of cycl
✍ Robert A. Galemmo Jr.; Brian L. Wells; Karen A. Rossi; Richard S. Alexander; Cel πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 222 KB

In this report refinements to the S4 ligand group leads to compound 19, an inhibitor of fXa with good potency in vitro and an improved pharmacokinetic profile in rabbit. The X-ray crystallographic study of a representative analogue confirms our binding model for this series.

ChemInform Abstract: The De Novo Design
✍ Robert A. Galemmo Jr.; et al. et al. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v