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NovoFLAP: A Ligand-Based De Novo Design Approach for the Generation of Medicinally Relevant Ideas

✍ Scribed by Damewood, James R.; Lerman, Charles L.; Masek, Brian B.

Book ID
120162857
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
296 KB
Volume
50
Category
Article
ISSN
0095-2338

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## Abstract ## Background Delivery of transgenes into specific tissues by adenovirus vectors (AdVs) relies on ablations of their natural tropism and on introduction of a new tropism. If the interaction with its natural receptor is ablated, a new packaging cell line is required to produce the AdV.