ATP-sensitive potassium channels in adult mouse skeletal muscle: Characterization of the ATP-binding site
β Scribed by R. Weik; B. neumcke
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 846 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0022-2631
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π SIMILAR VOLUMES
Patch-clamp techniques were used to study the effects of internal nucleotide diphosphates on the KAT e channel in mouse skeletal muscle. In inside-out patches, application of GDP (100 gM) and ADP (100 gM) reversibly increased the channel activity. In the presence of internal Mg 2+ (1 mM), low concen
The inside-out mode of the patch-clamp technique was used to study adenosine-5'-triphosphate (ATP)-sensitive K+ channels in mammalian skeletal muscle. Vanadate, applied to the cytoplasmic face of excised patches, was a potent activator of ATP-sensitive K+ channels. Divalent cations (Mg2+, Ca2+) were