Impairment of muscle glycogenolysis in McArdle's disease (myophosphorylase deficiency) leads to exercise intolerance and exercise-induced myalgia. The pathophysiology of these symptoms is not entirely clear. We used phosphorus magnetic resonance spectroscopy to measure muscle phosphate metabolite co
✦ LIBER ✦
ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle’s disease
✍ Scribed by Mervi Löfberg; Harri Lindholm; Hannu Näveri; Anna Majander; Anu Suomalainen; Anders Paetau; Anssi Sovijärvi; Matti Härkönen; Hannu Somer
- Book ID
- 117669381
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 70 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0960-8966
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## Abstract McArdle's disease is a common disorder of muscle metabolism and is due to myophosphorylase deficiency. The major complaint of patients with this disease is effort intolerance. Although the clinical features of affected patients are well known, their daily lifestyle is not well documente
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