ATMgermline mutations in women with familial breast cancer and a relative with haematological malignancy
✍ Scribed by Laura La Paglia; Anthony Laugé; Jérémie Weber; Jérôme Champ; Eve Cavaciuti; Antonio Russo; Jean-Louis Viovy; Dominique Stoppa-Lyonnet
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 416 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0167-6806
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📜 SIMILAR VOLUMES
Family history is a well-recognized risk factor for the development of breast cancer. The isolation of BRCA1 and BRCA2 genes, the two major predisposing genes in familial and to early onset breast and ovarian cancer, has resulted to the identification of a large number of families with mutations in
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio