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Asymmetric Synthesis with N-Heterocyclic Carbenes. Application to the Copper-Catalyzed Conjugate Addition.

✍ Scribed by Alexandre Alexakis; Caroline L. Winn; Frederic Guillen; Julien Pytkowicz; Sylvain Roland; Pierre Mangeney

Publisher
John Wiley and Sons
Year
2003
Weight
231 KB
Volume
34
Category
Article
ISSN
0931-7597

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✍ Khalidβ€…B. Selim; Yasumasa Matsumoto; Ken-ichi Yamada; Kiyoshi Tomioka πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 304 KB πŸ‘ 2 views

Copper-catalyzed asymmetric allylic alkylation is an efficient C Γ€ C bond-forming reaction for obtaining optically active compounds. [1] The use of hard alkyl nucleophiles such as Grignard or organozinc reagents usually produces S N 2' products (g products) with excellent regio-and enantioselectivit