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Efficient Chiral N-Heterocyclic Carbene/Copper(I)-Catalyzed Asymmetric Allylic Arylation with Aryl Grignard Reagents

✍ Scribed by Khalid B. Selim; Yasumasa Matsumoto; Ken-ichi Yamada; Kiyoshi Tomioka


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
304 KB
Volume
48
Category
Article
ISSN
0044-8249

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Efficient Chiral N-Heterocyclic Carbene/
✍ Khalid B. Selim; Yasumasa Matsumoto; Ken-ichi Yamada; Kiyoshi Tomioka 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 304 KB 👁 1 views

Copper-catalyzed asymmetric allylic alkylation is an efficient C À C bond-forming reaction for obtaining optically active compounds. [1] The use of hard alkyl nucleophiles such as Grignard or organozinc reagents usually produces S N 2' products (g products) with excellent regio-and enantioselectivit