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Asymmetric Synthesis with N-Heterocyclic Carbenes. Application to the Copper-Catalyzed Conjugate Addition

✍ Scribed by Alexandre Alexakis; Caroline L. Winn; Frederic Guillen; Julien Pytkowicz; Sylvain Roland; Pierre Mangeney


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
70 KB
Volume
345
Category
Article
ISSN
1615-4150

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Copper-catalyzed asymmetric allylic alkylation is an efficient C À C bond-forming reaction for obtaining optically active compounds. [1] The use of hard alkyl nucleophiles such as Grignard or organozinc reagents usually produces S N 2' products (g products) with excellent regio-and enantioselectivit