Asymmetric Synthesis of β-Hydroxy Amino Acids via Aldol Reactions Catalyzed by Chiral Ammonium Salts
✍ Scribed by Mettath, Sashikumar; Srikanth, G. S. C.; Dangerfield, Benjamin S.; Castle, Steven L.
- Book ID
- 123606132
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 88 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3263
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A variety of chiral fl-hydroxy-ct-amino acids and derivatives thereof can be synthesized enantioselectively using the aldol reaction of an aldehyde, the glycinate 1 and the cinchonidinederived catalyst 2, as indicated in Schemes I and 2 and Table 1.
Aldol reaction of methyl o-isocyanocarboxylates (CNCH(R)aXmc: R -H. Me, Et, i\_Pr)th kntaldehyde or acetaldchyde in the presence of 0.5-1.0 molX of a chiral ~aainoalkyl)ferrocenylphosphine-Sold(I) complex Rave optically active G-methoxycarbonyl-6,5-dialkyl-2-oxszolines with high ensntioaelcctivity i