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Asymmetric synthesis of α-substituted alkylphosphonates based on symmetrical dialkyl phosphites

✍ Scribed by O. I. Kolodiazhnyi; E. V. Grishkun; S. Sheiko; O. Demchuk; H. Thoennessen; P. Jones; R. Schmutzler


Book ID
105596572
Publisher
Springer
Year
1999
Tongue
English
Weight
482 KB
Volume
48
Category
Article
ISSN
1573-9171

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Cu-catalyzed asymmetric conjugate reduct
✍ Zheng-Chao Duan; Xiang-Ping Hu; Dao-Yong Wang; Sai-Bo Yu; Zhuo Zheng 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 249 KB

A series of chiral alkylphosphonates bearing b-stereogenic center were synthesized in good enantioselectivities (up to 95% ee) via the CuH-catalyzed asymmetric conjugate reduction of b-substituted a,b-unsaturated phosphonates under optimal conditions using Cu(OAc) 2 ÁH 2 O as the copper source, (R)-