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Enantioselective synthesis of optically active alkylphosphonates via Rh-catalyzed asymmetric hydrogenation of β-substituted α,β-unsaturated phosphonates

✍ Scribed by Zheng-chao Duan; Lian-zhi Wang; Xin-jian Song; Xiang-ping Hu; Zhuo Zheng


Book ID
113929677
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
637 KB
Volume
23
Category
Article
ISSN
0957-4166

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Cu-catalyzed asymmetric conjugate reduct
✍ Zheng-Chao Duan; Xiang-Ping Hu; Dao-Yong Wang; Sai-Bo Yu; Zhuo Zheng 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 249 KB

A series of chiral alkylphosphonates bearing b-stereogenic center were synthesized in good enantioselectivities (up to 95% ee) via the CuH-catalyzed asymmetric conjugate reduction of b-substituted a,b-unsaturated phosphonates under optimal conditions using Cu(OAc) 2 ÁH 2 O as the copper source, (R)-