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Asymmetric synthesis of (R)- and (S)-[2-2H1]glycine

✍ Scribed by Williams, Robert M.; Zhai, Dongguan; Sinclair, Peter J.


Book ID
120711367
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
201 KB
Volume
51
Category
Article
ISSN
0022-3263

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A short synthesis of (1S,2R)- and (1R,2R
✍ Jens Nieschalk; David O'Hagan πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 350 KB

A straightforward three step route to (1S,2R)-and (1R,2R)-[2H]-glycerols la and lb is reported. The key asymmetric step involves an AD-mix-l~ dihydroxylation on deuterium labelled Z-and E-allyl benzoates 4a and 4b. The route should facilitate the use of [2H]-glycerols la-ld in high enantiomeric puri