Asymmetric Synthesis of (1S,2R)-(1,2,3-Trihydroxypropyl)diphenylphosphine Oxide
β Scribed by A. O. Kolodyazhnaya; V. P. Kukhar'; O. I. Kolodyazhnyi
- Book ID
- 111608660
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 38 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1070-3632
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π SIMILAR VOLUMES
Two erythro-isomers of 2,2%-dimethoxy-4-(3-hydroxy-1-propenyl)-4%-(1,2,3-trihydroxypropyl)diphenyl ether, (7%S, 8%S)-9 and (7%R, 8%R)-9, were synthesized in seven steps, in which an improved method for the synthesis of the key intermediate 3 was developed. The absolute configuration of the target mo
Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (IR,2R)-and (1S,2R)-2,3-O-cyclohexylidene-l,2,3trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightly impr