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Studies on the synthesis of biphenylneolignans. Part 1: Enantioselective synthesis of (S,S)- and (R,R)-2,2′-dimethoxy-4-(3-hydroxy-1-propenyl)-4′-(1,2,3-trihydroxypropyl)diphenyl ether

✍ Scribed by Yi Yang; Chenglu Zhang; Guoren Yue; Pingyan Bie; Xinfu Pan

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
129 KB
Volume
13
Category
Article
ISSN
0957-4166

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✦ Synopsis

Two erythro-isomers of 2,2%-dimethoxy-4-(3-hydroxy-1-propenyl)-4%-(1,2,3-trihydroxypropyl)diphenyl ether, (7%S, 8%S)-9 and (7%R, 8%R)-9, were synthesized in seven steps, in which an improved method for the synthesis of the key intermediate 3 was developed. The absolute configuration of the target molecules was also confirmed.

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