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Asymmetric synthesis of quaternary tetrahydroisoquinoline-3-carboxylic acid derivatives

✍ Scribed by Valérie Alezra; Martine Bonin; Laurent Micouin; Henri-Philippe Husson

Book ID
104230157
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
74 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new route towards the asymmetric preparation of quaternary 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives has been developed. The key step involves an intramolecular Pictet-Spengler reaction of an oxazolidino ester.

📜 SIMILAR VOLUMES

Synthesis of 1,2,3,4-Tetrahydroisoquinol
Synthesis of 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Tic) Derivatives by Cycloaddition Approaches
✍ Sambasivarao Kotha; Nampally Sreenivasachary 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB 👁 1 views

A new and general synthetic methodology for the preparation of functionalized 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives by a cycloaddition strategy is described. The synthesis of various enyne building blocks 12, 13, 21, and 22 containing an α-amino acid moiety using Schiff base 8