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ChemInform Abstract: Asymmetric Synthesis of Quaternary Tetrahydroisoquinoline-3-carboxylic Acid Derivatives.

✍ Scribed by Valerie Alezra; Martine Bonin; Laurent Micouin; Henri-Philippe Husson


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
32
Category
Article
ISSN
0931-7597

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A new and general synthetic methodology for the preparation of functionalized 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives by a cycloaddition strategy is described. The synthesis of various enyne building blocks 12, 13, 21, and 22 containing an Ξ±-amino acid moiety using Schiff base 8