Asymmetric Synthesis of Quaternary Centers. Total Synthesis of (−)-Malyngolide
✍ Scribed by Trost, Barry M.; Tang, Weiping; Schulte, Jörg L.
- Book ID
- 126775722
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 49 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
Conformationally constrained chiral bis(oxazoline)-metal complex catalyzed asymmetric hetero Diels-Alder reactions of Danishefsky's diene and a variety of α-keto esters constructed quaternary carbon centers enantioselectively. The reaction was utilized in the synthesis of (-)-malyngolide.
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A highly efficient and versatile approach was applied for the total synthesis of the marine natural products (-)-malyngolide and (+)-tanikolide from isopropylidene L-and D-erythrose, using a common strategy.