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Asymmetric synthesis of (+)-phosphinothricin and (+)-2-amino-4-phosphonobutyric acid

✍ Scribed by Nobuto Minowa; Masao Hirayama; Shunzo Fukatsu

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 238 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91546-1

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✦ Synopsis

Asymmetric synthesis of (+)-phosphinothricin, (+)-2-amino-4-phosphonobutyric acid, and their enantiomers has been achieved by the Michael addition of chiral glycine Schiff bases to vinyl phosphorus compounds. Phosphorus analogues of glutamic acid are interesting as biologically active substances. Thus, (+)-phosphinothricin ((S)-(+)-l) and its alanylalanine

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