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Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam

✍ Scribed by Wolfgang Oppolzer; Stephane Rosset; Jef De Brabander

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
122 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.

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