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Asymmetric synthesis of functionalized benzo[a]quinolizine derivatives via a diastereoselective N-acyliminium ion cyclization

✍ Scribed by Yong Sup Lee; Soo Sung Kang; Jung Hoon Choi; Hokoon Park

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
601 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

A chiral synthesis of functionalized benzo[a]quinolizine derivative (5) has been accomplished starting from a chiral lactone 7. The key feature is the efficient control of the stereochemistry of ring juncture of the functionalized benzo[a]quinolizine derivative 5 by the Nacyliminium ion cyclization of chiral lactam llb.

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