Asymmetric Synthesis of Fluorinated Cyclic β-Amino Acid Derivatives through Cross Metathesis
✍ Scribed by Fustero, Santos; Sánchez-Roselló, María; Sanz-Cervera, Juan F.; Aceña, José Luis; del Pozo, Carlos; Fernández, Begoña; Bartolomé, Ana; Asensio, Amparo
- Book ID
- 121316756
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 91 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
## Abstract Asymmetric alkylation of (__S__)‐Boc‐BMI (**1a**, BMI = 2‐__tert__‐butyl‐3‐methylimidazolidin‐4‐one) and its α‐methyl derivative **1b** with 2‐fluoroallyl tosylate, subsequent mild acidic deprotection of the products **2a** and **2b**, and basic hydrolysis of the thus formed __N__‐methy
The electrophilic imino esters XF 2 CC(=NPG)CO 2 Me and imino phosphonates CF 3 CC(=NPG)P(O)(OR) 2 (PG = SO 2 Ph, Cbz, Boc) were transformed by nucleophilic and then electrophilic additions into fluorine-containing amino esters and amino phosphonates with two pendent alkene chains [Z = CO 2 Me, P(O