## Abstract This account concentrates on our new methodologies for the synthesis of fluorine analogues of amino acids and their derivatives using the Reformatsky‐type reactions of ethyl bromodifluoroacetate and ethyl dibromofluoroacetate with imines promoted by the Wilkinson catalyst. First, we pre
✦ LIBER ✦
Asymmetric Synthesis of γ-Fluorinated α-Amino Acid Derivatives.
✍ Scribed by Deepak M. Shendage; Roland Froehlich; Klaus Bergander; Guenter Haufe
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 34 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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The electrophilic imino esters XF 2 CC(=NPG)CO 2 Me and imino phosphonates CF 3 CC(=NPG)P(O)(OR) 2 (PG = SO 2 Ph, Cbz, Boc) were transformed by nucleophilic and then electrophilic additions into fluorine-containing amino esters and amino phosphonates with two pendent alkene chains [Z = CO 2 Me, P(O