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Asymmetric synthesis of enantiomerically pure (−)-(1′R,4′R)-dioxolane-thymine and its anti-HIV activity.

✍ Scribed by Chung K. Chu; Soon K. Ahn; H.O. Kim; J.Warren Beach; Antonio J. Alves; Lak S. Jeong; Qamrul Islam; Patrick Van Roey; Raymond F. Schinazi

Book ID: 104215965
Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 277 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79377-4

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✦ Synopsis

An asymmetric synthesis leading to the enannomerically pwe dioxolane-T hm been achieved and its crystal structure has been demmined and compared to the previousty reported racemate. (-)-(I 'R,I'R)-L%xolane-T war found to have potent and selective anti-HIV activity

in primary human lymphocytes.

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