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Asymmetric synthesis of 1,3-Dioxolane Nucleosides and their anti-HIV activities

โœ Scribed by C.K Chu; H.O Kim; S.K Ahn; A.J Alves; J.W Beach; L.S Jeong; P Van Roey; R.F Schinazi

Book ID
118392472
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
66 KB
Volume
15
Category
Article
ISSN
0166-3542

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Asymmetric synthesis of enantiomerically
Asymmetric synthesis of enantiomerically pure (โˆ’)-(1โ€ฒR,4โ€ฒR)-dioxolane-thymine and its anti-HIV activity.
โœ Chung K. Chu; Soon K. Ahn; H.O. Kim; J.Warren Beach; Antonio J. Alves; Lak S. Je ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 277 KB

## An asymmetric synthesis leading to the enannomerically pwe dioxolane-T hm been achieved and its crystal structure has been demmined and compared to the previousty reported racemate. (-)-(I 'R,I'R)-L%xolane-T war found to have potent and selective anti-HIV activity in primary human lymphocytes.