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Anti-HIV Activity of (−)-(2R,4R)-1- (2-Hydroxymethyl-1,3-dioxolan-4-yl)- thymine against Drug-Resistant HIV-1 Mutants and Studies of Its Molecular Mechanism

✍ Scribed by Chu, Chung K.; Yadav, Vikas; Chong, Youhoon H.; Schinazi, Raymond F.


Book ID
115460981
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
390 KB
Volume
48
Category
Article
ISSN
0022-2623

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Asymmetric synthesis of enantiomerically
✍ Chung K. Chu; Soon K. Ahn; H.O. Kim; J.Warren Beach; Antonio J. Alves; Lak S. Je 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 277 KB

## An asymmetric synthesis leading to the enannomerically pwe dioxolane-T hm been achieved and its crystal structure has been demmined and compared to the previousty reported racemate. (-)-(I 'R,I'R)-L%xolane-T war found to have potent and selective anti-HIV activity in primary human lymphocytes.