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Asymmetric Synthesis of Diethyl α-Amino-α-Alkyl-Phosphonates by Alkylation of the Chiral Schiff Base Derived from (+)-Ketopinic Acid and Diethylaminomethyl Phosphonate

✍ Scribed by Ferrari, M.; Jommi, G.; Miglierini, G.; Pagliarin, R.; Sisti, M.


Book ID
111966576
Publisher
Taylor and Francis Group
Year
1992
Tongue
English
Weight
427 KB
Volume
22
Category
Article
ISSN
0039-7911

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The asymmetric synthesis of α-chloro α-a
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A method is described for the synthesis of a-chloro-a-alkyl-and a-methyl-a-alkylphosphonic acids in either enantiomeric form and in high optical purity, based on the asymmettic allrylation of a-substituted bicyclic phosphonamides derived from a C2 symmetrical diamine.