Asymmetric synthesis of ?-amino-acid derivatives by alkylation of a chiral Schiff base
β Scribed by Yamada, Shun-Ichi; Oguri, Tomei; Shioiri, Takayuki
- Book ID
- 120282947
- Publisher
- The Royal Society of Chemistry
- Year
- 1976
- Tongue
- English
- Weight
- 178 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0022-4936
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π SIMILAR VOLUMES
A new double asymmetric induction in carbon-carbon bond formation is -achieved by the use of palladium chiral complexes in the alkylation of chiral Schiff bases1 derived from glycine. High diastereoisomeric excesses are obtained (90-999) using N.N-cyclohexylsulfamoylisobornyl derivatives and DIOP as
A short and convenient asymmetric synthesis of cl-alkyl a-amino acids is described, using (S)(-)-I-dimethoxymethyl-Z-methoxymethyl pyrrolidine (5) as chiral auxiliary reagent.
For the purpose of practical preparations of a variety of enantiomerically pure uncommon Β’x-amino acids, alkylations of the chiral glycine equivalent 5, which possesses axially chiral binaphthol as an auxiliary, with several electrophiles were investigated. The alkylation proceeded smoothly in satis