Asymmetric synthesis of deuterated and fluorinated aromatic α,α-disubstituted amino acid derivatives
✍ Scribed by Caroline E. Hartmann; Thomas Baumann; Michael Bächle; Stefan Bräse
- Book ID
- 108284574
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 537 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0957-4166
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## Abstract Asymmetric alkylation of (__S__)‐Boc‐BMI (**1a**, BMI = 2‐__tert__‐butyl‐3‐methylimidazolidin‐4‐one) and its α‐methyl derivative **1b** with 2‐fluoroallyl tosylate, subsequent mild acidic deprotection of the products **2a** and **2b**, and basic hydrolysis of the thus formed __N__‐methy
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the