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Organocatalytic Asymmetric Synthesis of α,α-Disubstituted α-Amino Acids and Derivatives
✍ Scribed by Cabrera, Silvia; Reyes, Efraim; Alemán, José; Milelli, Andrea; Kobbelgaard, Sara; Jørgensen, Karl Anker
- Book ID
- 118030823
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 616 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0002-7863
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the
An efficient route for the asymmetric synthesis of ct,a-disubstituted or-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chir