Asymmetric Synthesis of Cyclic α-Amino Acids by the Bislactim Ether Method
✍ Scribed by Prof. Dr. Ulrich Schöllkopf; Dipl.-Chem. Rolf Hinrichs; Dr. Ralph Lonsky
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 329 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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The electrophilic imino esters XF 2 CC(=NPG)CO 2 Me and imino phosphonates CF 3 CC(=NPG)P(O)(OR) 2 (PG = SO 2 Ph, Cbz, Boc) were transformed by nucleophilic and then electrophilic additions into fluorine-containing amino esters and amino phosphonates with two pendent alkene chains [Z = CO 2 Me, P(O
For the first time, an approach to cyclic ␣-amino phosphonate structures bearing a 5, 6benzo[1,3,2]diazaphosphorinan-4-one 2-oxide framework is described. The desired products, 4 and 5, were prepared by a modified Pudovik reaction, starting from the benzodiazaphosphorinanone derivative 1 and several