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Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir

✍ Scribed by David F Ewing; Virginie Glaçon; Grahame Mackenzie; Christophe Len

Book ID
104232339
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
57 KB
Volume
43
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES

A novel approach to unsaturated acyclic
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enyloxy]prop-2-enyl}cytosine have been prepared in good yield from uridine and 5-methyluridine by periodate cleavage followed by a double Wittig reaction which introduces two vinyl groups. The thymine derivative underwent ring closure metathesis to give a novel synthesis of d4T.

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## Abstract Baseline separation of some new acyclic nucleosides which are potential antiviral agents was achieved using cyclodextrin capillary zone electrophoresis (CD‐CZE). A method for the enantiomeric resolution of these compounds and determination of their enantiomeric purity was developed usin