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Asymmetric Synthesis of (−)-Aurantioclavine via Palladium-Catalyzed Intramolecular Allylic Amination

✍ Scribed by Suetsugu, Satoshi; Nishiguchi, Hiromi; Tsukano, Chihiro; Takemoto, Yoshiji


Book ID
121473184
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
437 KB
Volume
16
Category
Article
ISSN
1523-7060

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Synthesis of potential antiparisitic 5'-aminonucloesides such as 10 could not be accomplished using standard amination procedures. Palladium(0)-catalyzed amination of cyclic allylic acetates with benzylamine or phthalimide gave the corresponding protected amines. This method was then extended to the