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Asymmetric Synthesis of (+)- and (−)-Pauciflorol F: Confirmation of Absolute Stereochemistry

✍ Scribed by Kerr, Daniel J.; Miletic, Michael; Manchala, Narasimhulu; White, Jonathan M.; Flynn, Bernard L.


Book ID
120624215
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
760 KB
Volume
15
Category
Article
ISSN
1523-7060

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Asymmetric synthesis and absolute stereo
✍ Jack Deeter; Jeff Frazier; Gilbert Staten; Mike Staszak; Leland Weigel 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 331 KB

Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L