First asymmetric total synthesis of (+)-steganacin determination of absolute stereochemistry
โ Scribed by Kiyoshi Tomioka; Tsuneo Ishiguro; Kenji Koga
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 291 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
First enantioselective synthesis of quinolizidine 207I has been achieved and the absolute stereochemistry of natural quinolizidine 207I was determined to be 1S,4S,10S by the present chiral synthesis using GC analysis with b-dextrin chiral column on co-injection with racemate.
## Abstract For Abstract see ChemInform Abstract in Full Text.
Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L